• br Experimental All reagents were

  2025-04-09

  

  Experimental All reagents were analytical grade and were used without further purification. The morphology was characterized using a field emission scanning electron microscope (Philips XL-30 FESEMFeSEM, ZEISS SUPRA 40VP, Germany). The hydrogel sample used for SEM analysis was freeze dried. All e

• It has been proposed that a PrP pathogenic mechanism

  2025-04-08

  

  It has been proposed that a PrP pathogenic mechanism is a toxic gain of function secondary to the misfolding of mutated PrP. However, such a mechanism might not apply to all mutant PrP species, since some mutations had little effect on the stability and folding kinetics of PrP (Swietnicki et al., 19

• Since at least prospective cohort studies have been

  2025-04-03

  

  Since 2005, at least 14 prospective cohort studies have been conducted to clarify inconsistencies in the field, ten of which suggested a direct correlation between antibiotic use and atopy or wheezing later in life [51–60], three found no association [61–63], and one found positive association only

• Prestained Protein Marker (Triple color, EDTA free, 10-250 k

  2025-04-03

  

  The fluorescence in a fluorescent antibiotic can be derived either from functional groups with intrinsic fluorescence in an existing antibiotic, or via synthetic conjugation of a fluorophore to an antibiotic core to enable visualisation. Attachment of fluorophore to an antibiotic should ideally not

• Our surprising results show that AAD treated tumors adjacent

  2025-04-02

  

  Our surprising results show that AAD-treated tumors adjacent to adipose tissues and in steatotic liver continue to grow in the presence of a minimal number of microvessels. In non-adipose tumor models, the similar degree of vascular suppression is translated into marked suppression of tumor growth.

• 2X Taq PCR Master Mix (with dye) Androgen receptor transloca

  2025-03-31

  

  Androgen receptor translocates from the cytoplasm to the nucleus after binding to its ligands (Quigley et al., 1995). In the current study, although propofol did not significantly affect total androgen receptor protein levels, it significantly decreased nuclear androgen receptor levels. These findin

• In addition to differential expression of AR

  2025-03-29

  

  In addition to differential expression of AR protein primarily in surgical specimens, genetic alterations involving the AR gene have been documented in human HotStart™ 2X Green qPCR Master Mix cancer. Loss of heterozygosity at the AR locus was identified in all 3 informative cases of muscle-invasiv

• br Acknowledgements This work was supported by National Natu

  2025-03-29

  

  Acknowledgements This work was supported by National Natural Science Foundation of China (Nos. 21376172, 21528601 and 21621004) and the Natural Science Foundation of Tianjin from Tianjin Municipal Science and Technology Commission (Contract No. 16JCZDJC32300). Introduction Alzheimer’s disease

• In receptor binding terminology both receptor and acceptor

  2025-03-29

  

  In receptor binding terminology, both receptor and acceptor contain a receptive site for the ligand, although only the receptor induces a biological function. Moreover, the acceptor lacks an endogenous ligand. Many proteins have been described as receptors for toxic Aβ assemblies, implying a designe

• Recent results suggest that TARPs are

  2025-03-28

  

  Recent results suggest that TARPs are not the only auxiliary AMPAR subunits. Using a proteomic strategy (affinity purification of native AMPAR complexes followed by mass-spectrometric analysis), cornichon-related proteins (CNIHs) have been recently identified as components of the AMPAR protein micro

• br Experimental procedures br Results br Discussion br Ackno

  2025-03-27

  

  Experimental procedures Results Discussion Acknowledgments SRE and EBL contributed equally to this Prestained Protein Marker (Triple color, EDTA free, 10-250 kDa) work. SRE, EBL, and MJT designed experiments, SRE, EBL, MCH, and AEI conducted experiments, SRE and EBL analyzed data, and E

• In order to postulate its binding mode

  2025-03-27

  

  In order to postulate its binding mode in APN, EZ Cap™ Firefly Luciferase mRNA (5-moUTP) 13v was docked into the active site of APN (PDB code: 2DQM) using Sybyl_X 1.3. As illustrated in Fig. 5A, the catalytic zinc ion of APN was chelated by the hydroxamate moiety of 13v, and the S1, S1′ and S2′ poc

• The specific mechanisms underlying glutamine dependency are

  2025-03-24

  

  The specific mechanisms underlying glutamine dependency are still being explored, and current research indicates that the mechanisms likely vary between breast cancer subtypes. In HER2-positive breast cancer, increased levels of the transcriptional activator PGC-1α lead to expression of genes that m

• This study revealed that EAAT expression was increased weeks

  2025-03-03

  

  This study revealed that EAAT2 2X Probe qPCR Master Mix was increased 4–8 weeks after cauterization as our previous work (Park et al., 2009). RGC death could not be blocked despite activation of EAAT2, which is one of glutamate transporters in cone photoreceptors and some bipolar cells, in chronic o

• br Conclusions Several lines of evidence have

  2025-03-03

  

  Conclusions Several lines of evidence have been established, which support the adenosine kinase hypothesis of epileptogenesis, which is based on a sequence of events leading from acute RF 9 injury to initial downregulation of ADK, rise in extracellular adenosine, changes in astrocytic adenosine

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