• Several approved and or experimental drugs

  2025-04-22

  

  Several approved and/or experimental drugs, together with natural compounds, have been reported to induce autophagy in different cancer types [70], [71], [72] (Table 1). In the next paragraphs, we will review more in detail a group of these agents selected in relation to their promising future outco

• br Regulation of V ATPase assembly

  2025-04-21

  

  Regulation of V-ATPase assembly in response to changes in amino InstaBlue Protein Stain Solution levels A central regulator of cell growth and metabolism is mTORC1 [38]. mTORC1 integrates signals from nutrient availability and growth factor receptors to control such processes as protein and lipi

• Protein protein interaction networks are an

  2025-04-19

  

  Protein–protein interaction networks are an important ingredient for the system-level understanding of cellular processes. Such networks can be used for filtering and assessing functional genomics data and for providing an instinctive platform for annotating structural, functional and evolutionary p

• Previously using a P lacZ reporter gene

  2025-04-19

  

  Previously, using a P-lacZ reporter gene system, it has been shown that the β-galactosidase activity was 9-fold higher in the stationary phase Sulfo-NHS-Biotin when compared with those of the exponential phase [15]. Furthermore, inositol supplementation did not have a major effect on the expression

• Introduction The MMR system keeps the fidelity

  2025-04-19

  

  Introduction The MMR system keeps the fidelity of replication by repairing replication errors such as base-base mispairs and insertions/deletions. It plays a substantial role in restoring the fidelity of DNA and contributing to genome integrity [1]. The components of MMR are conserved in a broad ra

• In our studies of leucine and BCH in pancreatic

  2025-04-19

  

  In our studies of leucine and BCH in pancreatic islets and clonal insulin cell lines, we noticed that leucine was a slightly stronger stimulant of insulin release. Previous studies showed that leucine can be metabolized to CO2[11], [12], [13], [14] and can increase acetoacetate in pancreatic islets

• Prestained Protein Marker (Triple color, EDTA free, 10-250 k

  2025-04-19

  

  In the present study we sought to decipher the role of ATP-citrate lyase and of the mitochondrial NADH-dependent Mae in the oleaginous yeast Y. lipolytica. Indeed, although this yeast is one of the major models for lipid metabolism, the function of these enzymes is still not clear. As the study of t

• Illustrated in is the protocol we applied for the screens

  2025-04-19

  

  Illustrated in is the protocol we applied for the screens of novel furoic acids as ACL inhibitors. We constructed our furan carboxylate library that contained 1446 2-furoic Y-27632 dihydrochloride derivatives and 501 3-furoic acid derivatives by performing substructural searches of the ZINC datab

• br Conflict of interest statement br Funding br Acknowledgme

  2025-04-17

  

  Conflict of interest statement Funding Acknowledgments We thank the team at Medical and Collider-Accelerator Departments at BNL and for their support at NSRL. We thank Dr. Janice Pluth and Professor Peter O’Neill for useful discussions related to our work. Introduction The DNA damage re

• 3X (DYKDDDDK) Peptide br Interaction between ASK and TRX Thi

  2025-04-15

  

  Interaction between ASK1 and TRX Thioredoxins are small (∼12kDa) dithiol oxidoreductases ubiquitously expressed in species ranging from plants to archaea and mammals. They perform various biological functions, such as reducing protein disulfide bonds, supplying reducing equivalents to redox 3X (D

• br Aromatase inhibitors The aromatase enzyme

  2025-04-14

  

  Aromatase inhibitors The aromatase enzyme, P450arom, belongs to the super-family of P450 proteins which includes more than 480 members divided in 74 different families. P450arom is a unique member of family 19 [39], and is located in the endoplasmic reticulum of mammalian Prestained Protein Marke

• The Limitations of our data

  2025-04-14

  

  The Limitations of our data include the absence of functional/behavioral assessments and lack of direct comparison with females which would require additional studies and conceivably support sex-specific interventions for stroke [50]. Competing interests Acknowledgements This study was suppor

• The growth of cancer can control by inhibiting the

  2025-04-14

  

  The growth of cancer can control by inhibiting the rate of cell proliferation or increasing the rate of selective apoptosis and effectiveness of anticancer agents varies according to genetic constitution of cancer. Hence, we investigated the anticancer activity of arginase against different kinds of

• Citral or dimethyl octadien al is a mixture of two

  2025-04-12

  

  Citral or 3,7-dimethyl-2,6-octadien-1-al is a mixture of two stereoisomeric monoterpene aldehydes (the trans isomer geranial, citral A (40–62%)) and the cis isomer neral, citral B (25–38%) and serves one of the main constituent of essential oils of C. citratusis used in cosmetic, food, fungicides, p

• Serum concentrations of APP and antioxidants of the

  2025-04-09

  

  Serum concentrations of APP and antioxidants of the 10 queens with pyometra before surgery (T0), at day two (T1) and at day 10 (T2) after ovariohysterectomy are presented in Fig. 1. Concentrations of SAA and Hp were significantly lower (P  Discussion Acute phase protein responses were already desc

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