• Conformational changes are observed in the LBDs

  2021-12-21

  

  Conformational changes are observed in the LBDs after ligand binding, including partial cleft closure for GluN2A and complete cleft closure for GluN1. For GluN2A, additional conformational rearrangements in the protein and ligand may be required before the ligand can be accommodated within lobe 2. F

• br Acknowledgments The financial support from the National N

  2021-12-21

  

  Acknowledgments The financial support from the National Natural Science Foundation of China (Nos. 31460422 and 31060210), the Natural Science Foundation of Jiangxi Province, China (20171BAB204029 and 20143ACB20006), the Project of Science and Technology of Jiangxi Provincial Education Department,

• The classical genomic effects of GR come about through ligan

  2021-12-21

  

  The classical genomic effects of GR come about through ligand-bound GR homodimerizing in the nucleus and via direct binding to GREs on the target genes, bringing about transcriptional activation or repression. Examples of target genes up-regulated by activated GR include genes encoding β2-adrenergic

• The regulation of the stem cell

  2021-12-21

  

  The regulation of the stem cell compartment in CML is dynamic, in particular, during disease progression to a blast crisis and might involve a complex cross-regulation of Hh, Wnt, Notch, and hox signaling pathways (). Significant upregulation of Ptch1 and cyclin D1, upon other proteins, marks the bl

• br Summary br Conflict of interest br Acknowledgments This

  2021-12-21

  

  Summary Conflict of interest Acknowledgments This study was supported by Grant No. 2014/13/B/NZ7/02277 from the National Science Centre, Poland. Introduction Progesterone (P) is an anticonvulsant hormone (Backstrom et al., 1984, Herzog, 1995, Herzog, 1999, Frye et al., 2000, Reddy, 2002

• br Challenges and open questions Deepening our

  2021-12-20

  

  Challenges and open questions Deepening our understanding of PKC’s role in GSIS will require harnessing recently developed techniques and developing new tools. Here we describe three challenges remaining in the field and offer suggestions on experimental approaches to address them. PKC plays an

• Our previous work demonstrated that KDM regulates cellular o

  2021-12-20

  

  Our previous work demonstrated that KDM5 regulates cellular oxidative stress in Drosophila (Liu et al., 2014, Liu and Secombe, 2015). It is known that gut epithelial PF-573228 contacted by enteric commensal bacteria generate reactive oxygen species in response to microbial signals (Jones and Neish,

• Obesity may be associated with allergic

  2021-12-20

  

  Obesity may be associated with allergic diseases (including atopy, asthma, and allergic rhinitis) in children.9, 10, 11 Furthermore, body mass index (BMI) may be associated with bronchial hyper-responsiveness.9, 12 Nevertheless, the relationship between histamine skin reactivity and BMI is poorly un

• br Acknowledgments This review is based in part

  2021-12-20

  

  Acknowledgments This review is based in part on research conducted with financial support from the General Research Fund (17112914) of the Hong Kong Research Grant Council and from the Seed Funding Programme for Basic Research by University Research Committee of the University of Hong Kong (20151

• Starting from commercially available dioxaspiro

  2021-12-20

  

  Starting from commercially available 1,4-dioxaspiro[4.5]decan-8-ol, was prepared by the synthetic sequence illustrated in . Aromatic nucleophilic substitution of 1,4-dioxaspiro[4.5]decan-8-ol, followed by an 398 sale catalyzed deprotection efficiently gave . A - enriched mixture of (/=∼3/2) was obta

• Obestatin increased GnRH mRNA expression in the POA

  2021-12-20

  

  Obestatin increased GnRH mRNA expression in the POA, being the main place of GnRH synthesis (Goodman, 2015). Simultaneously, obestatin also caused a decrease in the GnRH mRNA expression in ME, without affecting the level of this peptide mRNA in AHA. A lack of differences observed in the mRNA level i

• br Materials and methods br Results br Discussion

  2021-12-20

  

  Materials and methods Results Discussion Neurotransmitter uptake is one of the most important aspects of synaptic transmission, it fact, the existence of a specific uptake system is one of the requisites that any neuroactive substance has to cover to be considered a neurotransmitter. It has

• br The hippocampus and spatial memory

  2021-12-20

  

  The hippocampus and spatial memory Numerous lines of evidence have implicated the rodent hippocampus in spatial forms of learning and memory (O’Keefe and Nadel, 1978). For example, hippocampal lesions produce robust and reliable deficits on spatial memory tasks such as the Morris watermaze in bot

• Beside these studies related to food several groups examined

  2021-12-20

  

  Beside these studies related to food, several groups examined the role of ghrelin in the actions of psychostimulants. Modulation of the ghrelin system and food restriction alter locomotor sensitization, DA release in the NAc, and CPP induced by cocaine, amphetamine, and nicotine (Abizaid et al., 201

• Even with all of the

  2021-12-20

  

  Even with all of the subunits present, the complex must also be correctly assembled for the enzyme to function properly. The complex is first assembled in the endoplasmic reticulum, with NCT and APH-1 binding together. They form the initial scaffold, so full-length PS can attach itself, and finally

16296 records 539/1087 page Previous Next First page 上5页 536537538539540 下5页 Last page