• Alzheimer s disease AD is

  2022-07-15

  

  Alzheimer's disease (AD) is a neurodegenerative disorder and characterized by the presence of abnormal filamentous protein inclusions in nerve cells of the brain [2]. The neuropathological hallmarks of AD were first reported by Alois Alzheimer and date back to 1907 [3], [4]. These inclusions are for

• Sildenafil The compounds f and a e were found

  2022-07-15

  

  The compounds 8f and 9a–e were found to be potent inhibitors of both isoforms of GSK-3 as characterized by IC50 values in the low nanomolar range. In addition, all of them showed good selectivities against other kinases. Substituents in the ortho- and para-positions of structure 8 and 9 lead to pote

• One clue to how evolution has solved such

  2022-07-15

  

  One clue to how evolution has solved such spatiotemporal challenges comes from studies revealing that lymph node (LN) organization is more complex than originally presumed, suggesting that steady-state microanatomical features are crucial for effective immune responses (reviewed by Qi et al., 2014).

• br Acknowledgement The author expresses her

  2022-07-15

  

  Acknowledgement The author expresses her sincere appreciation to Brian P. Kenealy, Ph.D. for his contributions to the series of studies described in this article that were conducted during his tenure in the lab, as a graduate student first and then a postdoctoral research fellow. She also thanks

• Diabetes induced damage results in peripheral

  2022-07-15

  

  Diabetes-induced damage results in peripheral nerve pathology that p-Cresyl sulfate correlates with clinical signs and symptoms. Nerve injury that results in structural changes can be measured through clinical neurological assessment, quantitative sensory testing, nerve conduction studies, and peri

• Through the analysis of various synthetic GPR agonists as re

  2022-07-14

  

  Through the analysis of various synthetic GPR40 agonists as reported in literature, we found that a number of these compounds contained a phenylpropanoic anatoxin a synthesis motif which was inspired from naturally occurring medium to long chain fatty acids. For instance, in the early period of dis

• Murine The identification of distinct expression domains in

  2022-07-14

  

  The identification of distinct expression domains in the limb suggested that these domains might have specific biological functions. We explored this possibility by determining enriched biological processes for each category using GO ontology term analysis (WebGestalt) (Zhang et al., 2005). Category

• br Mechanisms of gap junction internalization disaggregation

  2022-07-14

  

  Mechanisms of gap junction internalization: disaggregation, endocytosis and annular gap junctions It has been clearly shown that gap junction internalization can occur by a distinctive mechanism where one cell internalizes an entire gap junction via formation of double membrane structure termed a

• AD is an irreversible and progressive neurodegenerative

  2022-07-14

  

  AD is an irreversible and progressive neurodegenerative disease affecting the 1115 which insidiously destroys memory, thinking skills and cognition. Originally described in 1906 by German physician Alois Alzheimer, AD is characterized by the presence of intraneuronal neurofibrillary tangles of hype

• On the other hand with the exception in

  2022-07-14

  

  On the other hand, with the exception in muscle tissue, cGalR2 and cGalR2-L transcripts were also found to be widely distributed among the peripheral tissues at different levels (Fig. 2). The precise functions of cGalR2 and cGalR2-L in these peripheral tissues remain to be established, however, thei

• Immunohistochemistry using anti FFAR antibodies revealed imm

  2022-07-14

  

  Immunohistochemistry using anti-FFAR1 antibodies revealed immunoreactivity for FFAR1 in association with the cell membrane of the hepatocytes (Figure 2). However, the anti-FFAR2 antibody was not suitable for immunohistochemistry under the tested conditions (data not shown). Fatty liver is an import

• Finally the optimized leads and were tested

  2022-07-14

  

  Finally, the optimized leads (−)- and (−)- were tested in rat model of CIPN (3 and 30 mg/kg, po, qd, administered for 7 days) and the results have been shown in . Under acute set up, after single oral administration at 30 mg/kg, both the compounds exerted significant improvement of the NP condition

• Previous evidence suggests that PRC is an

  2022-07-14

  

  Previous evidence suggests that PRC2 is an important regulator of chromatin looping interactions in embryonic stem rat 4 . The new study by Donaldson-Collier and colleagues provides the first evidence that similar processes may be at play in lymphoma. It is still largely unclear, however, both in n

• Despite the two models for the HIV IN aptamer

  2022-07-14

  

  Despite the two models for the HIV-1 IN-aptamer complexes appeared to be comparable, disintegration assays revealed that 93-del inhibited C– or N-terminally truncated enzyme at the same extent, [18] whereas, T30695 required N-terminal domain (NTD) of the enzyme to exert its integrase inhibitory acti

• br Conclusion br Disclosure of interest br

  2022-07-14

  

  Conclusion Disclosure of interest Introduction The Joint United Nations Program on HIV and AIDS (UNAIDS) proposed the ambitious global goal of achieving the "90-90-90" target by 2020 and ending the HIV epidemic by 2030 (Barton-Knott, 2014). One important measure is to monitor the incidence

16136 records 409/1076 page Previous Next First page 上5页 406407408409410 下5页 Last page