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Whether similar mechanisms play a role in adiponectin signal
2024-06-19
Whether similar mechanisms play a role in adiponectin signal transduction and whether additional proteins are recruited to adiponectin receptors via APPL1 has not been analysed so far. Although it has been clearly established that APPL1 is a downstream adaptor protein in adiponectin signal transduct
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Our previous work fails to show any maternal
2024-06-19
Our previous work fails to show any maternal effect with blockade of 5-HT2A receptor, as acute and repeated treatment of MDL100907 does not alter maternal behavior at the behaviorally active doses (Chen et al., 2014). In the present study, MDL100907 pretreatment attenuated the maternal disruptive ef
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We have previously shown that the antinociceptive effect
2024-06-19
We have previously shown that the antinociceptive effect of tramadol, an analgesic that, like paracetamol is able to increase serotonin levels within CNS, is potentiated or antagonized respectively by a 5-HT1A/B nonspecific cp-690550 mg blockade or activation (Rojas-Corrales et al., 2000). Moreover
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br Material and methods br Results br Discussion To
2024-06-19
Material and methods Results Discussion To develop a novel regenerative and/or neuroprotective therapy for optic neuropathy, including glaucoma, numerous studies have tested new candidates favorable to RGC survival and axon regeneration. Among the many candidate drugs, AdoR modulators are o
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There has been growing interest over
2024-06-19
There has been growing interest over computational methods to predict the biological activity by chemical structure, so as to decide whether it GSK621 has objective qualities or not. In this contribution, the well-known method, which is called quantitative structure–activity relationship (QSAR) [13,
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Search sphere This sphere includes the acetylcholine
2024-06-19
Search sphere 1: This sphere includes the L-Arabinose sale binding site between the α–γ subunits. The center point of the search area was located at x=35.26, y=77.67, z=137.74 and the initial search radius was set to 27Å which assures that the corresponding area outside the channel pore of the two
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br Results br Discussion Our finding that AXL overexpression
2024-06-18
Results Discussion Our finding that AXL overexpression is significantly associated with poor survival in patients with high-grade serous OC is consistent with previous reports indicating that AXL regulates tumor growth in some cancers, as well as reports showing that AXL activity is involved i
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br Acknowledgements We thank Dr
2024-06-18
Acknowledgements We thank Dr. Stefan Schulte-Merker and his group members at the Hubrecht Institute (Utrecht, the Netherlands) for their invaluable support of the zebrafish studies. Our work is supported by grants from the Dutch Cancer Society (KWF) and the Netherlands Organisation for Scientific
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To maintain ATP levels postmortem
2024-06-18
To maintain ATP levels, postmortem muscle mobilizes its glycogen reserves to yield Anisomycin 6-phsphate that proceeds through glycolysis. Glycogen degradation was affected by the interaction between treatment and time (P decreases as muscle pH declines until complete inactivation is reached at pH5.
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In addition to attracting immune cells to the site
2024-06-18
In addition to attracting immune cells to the site of injury, ROS also participate in proliferative responses during compensatory proliferation and regeneration. In Xenopus tadpoles, tail amputation induces sustained production of ROS over the span of regeneration, and decreasing ROS levels, especia
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Recently whey products have been added
2024-06-18
Recently, whey products have been added to nutritional beverages to boost their antioxidant capacity. Supplementation of a lemon drink with 1% WP hydrolyzed by subtilisin increased the antioxidant activity of the beverage from 0.75 to 7.79 mmol of TE/L (Athira et al., 2014). In addition, a flavored
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Although our sample size is not enough
2024-06-18
Although our sample size is not enough to conclude that there is no great genetic variation of the AR gene in most New World monkeys, it would be reasonable to state that the microsatellite region in the exon 1 of the androgen receptor gene of New World monkeys (platyrrhine) is relatively shorter th
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Moreover a multiple regression analysis using the
2024-06-18
Moreover, a multiple regression analysis using the 1-year MMSE score as a dependent variable was conducted. The result showed that serum Spautin-1 levels at admission did not affect the MMSE score 1 year later (β = 0.10, p = 0.639). Discussion In this study, serum Aβ42 levels were significantly
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AMP activated protein kinase AMPK is composed of
2024-06-18
AMP-activated protein kinase (AMPK) is composed of α-, β-, and γ-subunits [17,18]. Phosphorylation of α-subunit at Thr-172 residue is essential for AMPK activation [17,18]. The serine/threonine kinase coordinates metabolic pathways in response to energy supply and demand [17,18]. Studies have shown
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Recent results suggest that TARPs are not the
2024-06-18
Recent results suggest that TARPs are not the only auxiliary AMPAR subunits. Using a proteomic strategy (affinity purification of native AMPAR complexes followed by mass-spectrometric analysis), cornichon-related proteins (CNIHs) have been recently identified as components of the AMPAR protein micro
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