• br Methods br Results br Discussion

  2018-11-08

  

  Methods Results Discussion The structural and functional immaturity of the differentiated cardiomyocytes are major obstacles for developing hPSC-VCM-based cell replacement therapies (Kong et al., 2010; van den Heuvel et al., 2014). Although a number of studies showed that the overall matura

• br Results br Discussion In this

  2018-11-08

  

  Results Discussion In this study, we integrated transcriptome and proteome data and characterized the inventory of HSPCs and their immediate myeloid committed progeny (LS−K) (Figure S6). With almost 20,000 identified expressed genes including more than 3,000 significantly regulated ones, these

• br Acknowledgments br Introduction The intestinal epithelium

  2018-11-08

  

  Acknowledgments Introduction The intestinal epithelium provides a paradigmatic model for understanding stem cell organization and dynamics in highly proliferative tissues. The past decade has seen numerous breakthroughs in our understanding of intestinal stem cells (ISCs). Prior to 2007, the e

• AMD3100 Paper pools were established by searches of the PubM

  2018-11-08

  

  Paper pools were established by searches of the PubMed database, which is accessible through the NIH National Library of Medicine (NIH/NLM). Data bank searches were performed separately to identify hESC- and hiPSC-related publications using the search strings described earlier (Guhr et al., 2006; Mü

• Based on these principles we speculated that the use

  2018-11-08

  

  Based on these principles, we speculated that the use of rBC2LCN as a cargo of cytotoxic agent would provide an efficient strategy to eliminate hPSCs. Here we generated a recombinant lectin-toxin fusion protein by fusing rBC2LCN with 23 kDa of a catalytic domain of Pseudomonas aeruginosa exotoxin A

• Our objective was to determine

  2018-11-08

  

  Our objective was to determine how the culturing of CD34+ Amyloid β-Peptide (1-42) under conditions that influence ARNT complex formation might affect the expansion of HSPCs. We hypothesized that the use of culture conditions that stabilize HIF-1α and antagonize the AhR protein would promote the ex

• The pleiotropic nature of FGF

  2018-11-08

  

  The pleiotropic nature of FGF2 and its variety of downstream effects make generation of highly pure active protein essential. Heparin chromatography has been used for purification of 18kDa FGF2 isoform. However, subsequent heparin contamination in purified FGF2 preparations has been previously descr

• Our objective was to determine

  2018-11-08

  

  Our objective was to determine how the culturing of CD34+ thymidylate synthase inhibitor under conditions that influence ARNT complex formation might affect the expansion of HSPCs. We hypothesized that the use of culture conditions that stabilize HIF-1α and antagonize the AhR protein would promote

• Hematopoietic stem cells HSCs maintain the turnover of red

  2018-11-08

  

  Hematopoietic stem phosphodiesterase inhibitors (HSCs) maintain the turnover of red blood cells, platelets, and immune cells. They reside in the bone marrow, where several cell types contribute to their regulation (Lo Celso et al., 2011; Morrison and Scadden, 2014). How the concerted action of mult

• These studies add to a growing body

  2018-11-08

  

  These studies add to a growing body of information related to the role of p38 MAPK signaling in skeletal muscle progenitor cells. Over a decade ago, a requirement for p38 in the regulation of rodent myoblast differentiation was defined (Cuenda and Cohen, 1999; Zetser et al., 1999). Based on these pr

• In the present study we undertook further testing

  2018-11-07

  

  In the present study we undertook further testing to explore whether fast food restaurant access around schools differed by area-level of disadvantage of schools in major city areas. Within the major city areas, primary and secondary schools located within more disadvantaged neighbourhoods were loca

• It is technically challenging to extract

  2018-11-07

  

  It is technically challenging to extract proteins of interest from bone due to the abundance of collagens and minerals. A pilot study using HCl/Urea extraction identified 119 proteins in OA subchondral bone with only 7 proteins shared between the low and high damage regions. This data suggests that

• A central challenge to advancing therapy

  2018-11-07

  

  A central challenge to advancing therapy for progressive PTC is to improve the responses to tyrosine kinase receptor therapy, while minimizing toxicity. So far, the response rates are typically 20% (range 0–45%) and there was substantial toxicity documented from trials using tyrosine kinase receptor

• br Methods br Results As we have published

  2018-11-07

  

  Methods Results As we have published previously, we did not find any statistically significant differences between the two cohorts based on vascular risk factors, clinical characteristics and neuroimaging data (Jove et al., 2015b). We observed DWI abnormalities in 115 (40.9%) patients. Moreove

• Participant baseline characteristics and outcome measures ar

  2018-11-07

  

  Participant baseline characteristics and outcome measures are summarized in Tables 1 and 2. The mean FPG, 1h, and 2h plasma order Exendin-3 (9-39) amide levels were 4.3mmol/l, 7.7mmol/l, and 6.6mmol/l, respectively. Using the IADPSG criteria, there were 1779 (N=12,889, 13.8%) women diagnosed with GD

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