• Based on these principles we speculated

  2018-10-24

  

  Based on these principles, we speculated that the use of rBC2LCN as a cargo of cytotoxic agent would provide an efficient strategy to eliminate hPSCs. Here we generated a recombinant lectin-toxin fusion protein by fusing rBC2LCN with 23 kDa of a catalytic domain of Pseudomonas aeruginosa exotoxin A

• citco The activity of CXCL through CXCR

  2018-10-24

  

  The activity of CXCL12(5-67) through CXCR3 receptor has been shown before (Denoyer et al., 2012; Zhu et al., 2009). Here we aimed to confirm this finding using CXCL9, a natural ligand of CXCR3. NSCs pre-treated with CXCL9 were not susceptible to the CXCL12(5-67) apoptotic effects. The effect of CXCL

• Pax is a well known neurogenic transcription factor

  2018-10-24

  

  Pax6 is a well-known neurogenic transcription factor that is essential for the development of multiple neural tissues (Gehring and Ikeo, 1999; Georgala et al., 2011; Zhang et al., 2010). Due to its important role in neuronal development, Pax6 was often included in the initial screening for essential

• br Results br Discussion We have developed an automated segm

  2018-10-24

  

  Results Discussion We have developed an automated segmentation, classification, and localization measurement algorithm (Figure 7A) for analysis of confocal and two-photon microscopy images of HSCs, osteoblasts, and bone obtained through intravital microscopy of mouse bone marrow. In particular

• br Results br Discussion The

  2018-10-24

  

  Results Discussion The Wnt signaling pathway has emerged as the dominant self-renewal pathway for various adult-type stem cells and is required for maintenance of embryonic as well as induced pluripotent stem cells. In the hematopoietic system, only mild increased Wnt dosages result in higher

• Gene set enrichment analysis GSEA of developmentally

  2018-10-24

  

  Gene set enrichment analysis (GSEA) of developmentally regulated genes showed that transcripts from bivalent genes were preferentially upregulated in Dicer-deficient ESCs, comparable with a set of Targetscan-predicted target genes of miR-290–295 (Figure 3B). Eight sets of developmental genes were us

• Our data suggest that the region where the duct transitions

  2018-10-24

  

  Our data suggest that the region where the duct transitions into an acinus harbors the meibomian gland progenitors, and localized hyperproliferation previously reported in this region (Parfitt et al., 2013) could constitute a transiently amplifying cell population. From this, we propose that LRCs ar

• T cell analysis within the spinal cord showed a

  2018-10-24

  

  T cell analysis within the spinal cord showed a significantly increased number of CD4+ T cells in animals treated with MSC/IL-13. The specific subtype of the T cells is unclear, and previous studies from our group revealed that specific T cell immunophenotyping after CNS injury can be challenging an

• Using three different unambiguous combinations of markers

  2018-10-24

  

  Using three different unambiguous combinations of markers, we found that long-term cultures of scaffold-based and scaffold-free TOs contained early and late spermatogonia. Importantly, throughout the culture period, a proportion of the germ serine protease inhibitors stained positive for a marker of

• Furthermore a dramatic shift in MSC marker expression was se

  2018-10-24

  

  Furthermore, a dramatic shift in MSC marker expression was seen, including an increased positivity for CD34 (Wood et al., 1997; Fina et al., 1990; Krause et al., 1994). There is evidence that CD34 is a marker for diverse progenitors including MSCs (Copland et al., 2008). In the current study, mRNA t

• br Introduction For Crocco s equation

  2018-10-24

  

  Introduction For Crocco\'s equation given on the interval 0 0, f ∈ L1(0, 1), it MK2 inhibitor is possible to set various boundary problems. First of all, a typical boundary problem can be set: Aside from this one, a boundary problem homogeneous in φ(h) can be set: as well as a combined hom

• This research adds to the body

  2018-10-24

  

  This research adds to the body of evidence showing the long-term health benefits of years of schooling. A recent review of the evidence on the impact of education on health finds health benefits arise from receiving high quality education (Cohen & Syme, 2013). Relating education and literacy, qualit

• There are several policy implications for these results Sinc

  2018-10-24

  

  There are several policy implications for these results. Since 2006 in an attempt to reduce financial barriers, delivery care has been exempt from user fees in Burkina Faso (Ridde, Richard, Bicaba, Queuille, & Conombo, 2011). While user fee reductions have been shown to increase service coverage, ma

• Nutlin3a This study focuses on ultimate reasons for

  2018-10-24

  

  This study focuses on ultimate reasons for certain kinds of consumer behaviour. Specifically, it examines how external stimuli with adaptive objectives (e.g., mate selection, investment in family care and security) can play a more decisive role than our cognitive capabilities in modifying our decisi

• As seen in Table the majority

  2018-10-23

  

  As seen in Table 1, the majority of firms in our sample are not listed on the stock market as well as they are SME. Firms in our sample have around 416 employees where their exports represent only 6% of their revenues. Overall, figures represent what is expected: Firms listed on the stock market are

15962 records 1060/1065 page Previous Next First page 上5页 10561057105810591060 下5页 Last page