• JNK signaling promotes the expression of cytoprotective gene

  2018-11-08

  

  JNK signaling promotes the expression of cytoprotective genes in flies, which contributes to tissue homeostasis loss in aged guts (Biteau et al., 2008). We found that JNK activity was increased in dbr- and ptc-depleted guts, and further inhibition of JNK activity in these guts effectively suppressed

• br Results br Discussion Graft failure

  2018-11-08

  

  Results Discussion Graft failure and rejection for patients with acquired SAA remains as one of the important and life-threatening complications, especially in haplo-HSCT (Wagner et al., 1996; Passweg et al., 2006). The EBMT showed that for patients receiving HLA-identical sibling grafts, the

• The importance of the finding that the prostaglandin pathway

  2018-11-08

  

  The importance of the finding that the prostaglandin pathway is selectively downregulated by MSX2, but not MSX1, is 2-fold; i) this functional disparity between MSX1 and MSX2 provides a mechanistic insight into a cellularization event during muscle dedifferentiation and ii) it also demonstrates that

• br Conclusion In this study we established iNSCs

  2018-11-08

  

  Conclusion In this study, we established iNSCs from two different mouse strains (C3H and C57BL/6). These two iNSCs exhibited distinct reprogramming status in terms of NSC markers expression, silencing of transgenes, and in vitro differentiation potential. Our data suggest that the genetic backgro

• Recent publications provide inconsistent results whether

  2018-11-08

  

  Recent publications provide inconsistent results whether the overexpression of KLF4 is consistently accompanied with a more favorable outcome in all gastrointestinal cancer types. In HCC the DNA Damage DNA Repair Library pattern of KLF4 is significantly increased compared to corresponding adjacent n

• br Methods br Results br Discussion

  2018-11-08

  

  Methods Results Discussion The structural and functional immaturity of the differentiated cardiomyocytes are major obstacles for developing hPSC-VCM-based cell replacement therapies (Kong et al., 2010; van den Heuvel et al., 2014). Although a number of studies showed that the overall matura

• br Results br Discussion In this

  2018-11-08

  

  Results Discussion In this study, we integrated transcriptome and proteome data and characterized the inventory of HSPCs and their immediate myeloid committed progeny (LS−K) (Figure S6). With almost 20,000 identified expressed genes including more than 3,000 significantly regulated ones, these

• br Acknowledgments br Introduction The intestinal epithelium

  2018-11-08

  

  Acknowledgments Introduction The intestinal epithelium provides a paradigmatic model for understanding stem cell organization and dynamics in highly proliferative tissues. The past decade has seen numerous breakthroughs in our understanding of intestinal stem cells (ISCs). Prior to 2007, the e

• AMD3100 Paper pools were established by searches of the PubM

  2018-11-08

  

  Paper pools were established by searches of the PubMed database, which is accessible through the NIH National Library of Medicine (NIH/NLM). Data bank searches were performed separately to identify hESC- and hiPSC-related publications using the search strings described earlier (Guhr et al., 2006; Mü

• Based on these principles we speculated that the use

  2018-11-08

  

  Based on these principles, we speculated that the use of rBC2LCN as a cargo of cytotoxic agent would provide an efficient strategy to eliminate hPSCs. Here we generated a recombinant lectin-toxin fusion protein by fusing rBC2LCN with 23 kDa of a catalytic domain of Pseudomonas aeruginosa exotoxin A

• Our objective was to determine

  2018-11-08

  

  Our objective was to determine how the culturing of CD34+ Amyloid β-Peptide (1-42) under conditions that influence ARNT complex formation might affect the expansion of HSPCs. We hypothesized that the use of culture conditions that stabilize HIF-1α and antagonize the AhR protein would promote the ex

• The pleiotropic nature of FGF

  2018-11-08

  

  The pleiotropic nature of FGF2 and its variety of downstream effects make generation of highly pure active protein essential. Heparin chromatography has been used for purification of 18kDa FGF2 isoform. However, subsequent heparin contamination in purified FGF2 preparations has been previously descr

• Our objective was to determine

  2018-11-08

  

  Our objective was to determine how the culturing of CD34+ thymidylate synthase inhibitor under conditions that influence ARNT complex formation might affect the expansion of HSPCs. We hypothesized that the use of culture conditions that stabilize HIF-1α and antagonize the AhR protein would promote

• Hematopoietic stem cells HSCs maintain the turnover of red

  2018-11-08

  

  Hematopoietic stem phosphodiesterase inhibitors (HSCs) maintain the turnover of red blood cells, platelets, and immune cells. They reside in the bone marrow, where several cell types contribute to their regulation (Lo Celso et al., 2011; Morrison and Scadden, 2014). How the concerted action of mult

• These studies add to a growing body

  2018-11-08

  

  These studies add to a growing body of information related to the role of p38 MAPK signaling in skeletal muscle progenitor cells. Over a decade ago, a requirement for p38 in the regulation of rodent myoblast differentiation was defined (Cuenda and Cohen, 1999; Zetser et al., 1999). Based on these pr

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